chongzichongzi
更新:请大家在给看看,这些信息能判断是得过乙肝有痊愈了吗,那会传染家人吗
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2009-07-28 20:36:00
Your liver function is still abnormal, suggesting chronic viral hepatitis. Usually, viral liver damage will causes ALT elevated more than AST. 50 is the upper limit of ALT and AST. Some labs may have 40 as the upper limit. Your enzyme elevation is mild only. I would recommend you adopt a healthy life style. No alcohol at all. Monitor your liver enzyme every 6 mon to every year and f/u rountinely with a GI doctor.
S Ag neg and S Ab positive indicating you are in the recovery stage. Although C Ab positive is not a good sign. You may need to find out what is your E Ag and E Ab status. E Ag positive indicate active viral replication and is contagious. My judgement is that most likely your E Ag is neg. However, you need to find out. In case E Ag is positive, you need to find out your viral load by DNA PCR.
All your close family member still need HBV vaccination.
Your insurance should cover all the expense, don't worry about it.
Your panel is consistent with chronic hepatitis with low viral load.
Every year, among HBV carriers, there are 0.7% patients spontaneously clear the virus from their body using their own immune response. However, medications such as DNA polymerase inhibitor can only inhibit the virus but not clear the virus. If you are taking anti-viral medication, you should continue with it. Otherwise, there could be rebound.
Either way, you should still monitor your liver enzyme every 6 mon and have all your close family members get vaccination.
AST and ALT are enzymes found in liver cells. They will get released and become detected in the blood when there is liver cell damage. The higher the enzyme level, the more liver cells have been damaged. Viral damage cause ALT higher than AST. ALcoholic damage causes AST elevated more. This is the reason that I said you have chronic hepatitis, mild form.
Have you tried any medication?
Could you please tell me more about your history? When you were found to be HBV +? How was the Ag and Ab panel originally? How was your enzyme panel originally?
It seems that the infection occured sometime between 2002 and recently. Now you are in the recovery phase. You need f/u. I would recommend you get a referal from you family doctor for GI doctor instead of the "3 mon f/u". Although nobody will initiate any antiviral treatment now for you because there is no indication for your case, you need to f/u with a specialist in the field instead of a family doctor.
HBV panel may not be a rountine OB exam. Your wife needs to get her HBV panel asap.
Your new born should get HBV vaccination #1 already, which is now a required vaccine for all children in US. Please double check with the peds doctor.
One thing that you need to think about is your newborn's status. If you don't know exactly when you got infected and your HBV e Ab is now positive, there must be a period in the past that you were HBV e Ag +. At that time, you were highly contagious. If I were you, I would get the baby's HBV panel when he or she needs some other blood workup in the near future and make sure that all 3 HBV vaccinations will be given meanwhile. It is really a pain in the neck to get blood from newborns and whether you know it or later will not change the management. I recommend you do it when there is some other need for blood draw.
谢谢chongzichongzi。
你比family doctor知道的还多,呵呵。
还有几个问题向你请教一下,我自己也google了些,有时越看越糊涂。
1. f/u是定期检查的意思吗,GI是不是Gastroenterologist的简写
2. 好像没有测试能检查出我啥时 got infected? panel 结果只表明我过去感染过,现正在恢复,那我咋判断我是不是已转成慢性肝炎了呢?我现在的case到底有没有传染性呢?
3. 我2002年的HBsAg: negative, 但并有没有完整的panel信息, 可以排除我2002年以前感染吗?
4. 你建议我现在就去看speciallist, 还是三个月后测过后再去,这个我也在犹豫
5.我老婆查了她怀孕时去年8月做的test, HBsAg:NR. 那就说明截至那是她没事。但我已让她和OB联系,尽快测一下hbv panel,希望没事,然后建议她打从速打疫苗
6. 谢谢你提到baby的事。 这也是我最揪心的。 宝宝一出生就打第一次疫苗,到4个月时,已达了三次。应该打完疫苗了。
whether you know it or later will not change the management, 如果我理解的没错,现在让宝宝测和以后找机会抽血时在测,从治疗角度没区别,所以我不想现在折腾宝宝,太小。希望我理解的是对的。
7. 按照你的理解,我见专家的话,是不是要肝穿刺测试呢,不知道专家还能测试啥。我panel和B超都做过了。
8.我有必要想办法也找国内专家咨询吗?
多谢多谢,请百忙中给解释解释。
Both your wife and baby need HBV booster every 5-10 years, because the HBs Ab titer gradually decrease and lose the protection effect finally. There is quantative test for HBs Ab titer now. Your wife can have the blood draw every 5 yrs and have booster if necessary. Your baby need at least one blood draw with HBV full panel (HBs Ab-Ag, HBV c Ab, E Ag and Ab) and HBV s Ab titer by age 1 1/2 to make sure there is protective titer of Ab. A booster is necessary immediately if S Ab titer is not high enough. Babies sometimes have problem of generating enough immune response because their systems are still in the developing stage.
Remember, the only protective Ab is HBV s Ab.
Moreoever, I would recommend you be cautious regarding close contact with your baby. Avoid your body fluid get into any skin broken area or mucosa of the baby.
到底了
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