The regimen most commonly recommended for first line treatment of H. pylori is triple therapy with a PPI (lansoprazole 30 mg twice daily, omeprazole 20 mg twice daily, pantoprazole 40 mg twice daily, rabeprazole 20 mg twice daily, or esomeprazole 40 mg once daily), amoxicillin (1 g twice daily), and clarithromycin (500 mg twice daily) for 7 to 14 days. We suggest treatment for 10 days to two weeks.
Metronidazole (500 mg twice daily) can be substituted for amoxicillin in penicillin-allergic individuals.
Eradication rates of 70 to 85 percent
---from uptodate